This study investigates the safety and immune response of an investigational vaccine for preventing lower respiratory tract disease caused by respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). These are viruses that can lead to lung infections. The study involves healthy adults aged 18 to 49 years and those 60 …
This study investigates bronchiectasis, a chronic lung condition where the airways in the lungs become enlarged due to weakened walls. This can lead to symptoms like shortness of breath, coughing up mucus and sometimes blood, wheezing, and frequent lung infections. The study aims to explore the effects of an investigational …
This study investigates the long-term safety and tolerability of an investigational medication in adults with different forms of multiple sclerosis, including relapsing multiple sclerosis (RMS), primary progressive multiple sclerosis (PPMS), and non-relapsing secondary progressive multiple sclerosis (NRSPMS). Multiple sclerosis is a condition where the immune system mistakenly attacks the protective …
This study investigates treatment options for people with advanced colorectal cancer, specifically those with certain genetic profiles like KRAS, NRAS, and BRAF wild-type. The purpose is to compare how long participants remain free from disease progression and overall survival when treated with investigational medication and chemotherapy versus standard treatments.Participants will …
This study investigates the effectiveness of an investigational medication when used with standard treatment for people with diffuse large B-cell lymphoma (DLBCL). DLBCL is a type of cancer that affects the lymphatic system, which is part of the body's immune system. The study aims to determine if this combination can …
This study investigates the effects of an investigational medication regimen for treating locally advanced or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma (mGEA). Cancer occurs when cells in a part of the body grow uncontrollably. The investigational medications include ABBV-400 and Budigalimab, which are being studied alongside Fluorouracil and Leucovorin, …
Who can participate: Individuals aged 18 to 65 years diagnosed with Condition X and meeting specific health criteria are eligible to participate. Key eligibility factors include no prior treatment with similar investigational medications and stable overall health.Study details: Participants will be randomly assigned to receive either the investigational treatment or …
This study investigates the effects of an investigational medication on young children aged 2 to under 6 years who have uncontrolled asthma or recurrent severe asthmatic wheezing. Asthma is a condition where the airways in the lungs become narrow and swollen, making it hard to breathe. This study will help …
This study investigates the safety, tolerability, and effectiveness of using a person's own stem cells for treating severe Sickle Cell Disease (SCD). Sickle Cell Disease is a condition where the red blood cells, which carry oxygen, are shaped like a sickle and can block blood flow. This study aims to …
This study investigates the effectiveness of combining an investigational medication with lenalidomide and dexamethasone in people with high-risk smoldering multiple myeloma, a condition where abnormal plasma cells are present in the bone marrow but do not cause symptoms like bone damage or kidney problems. The purpose is to see if …
