This study investigates the safety, tolerability, and activity of a single dose of an investigational medication in adults with osteogenesis imperfecta (OI). Osteogenesis imperfecta is a genetic disorder characterized by fragile bones that break easily. The medication being studied is a type of antibody that targets a specific protein in …
This study investigates the use of an investigational gene therapy for individuals with phenylketonuria (PKU). PKU is a genetic disorder that affects the body's ability to break down phenylalanine (Phe), a component of proteins. If not managed properly, high levels of Phe can harm the brain and nerves. Current treatments …
This study investigates bronchiectasis, a long-lasting lung disease that causes the air passages in the lungs to enlarge due to weakened airway walls. Symptoms include shortness of breath, coughing up mucus or blood, wheezing, and frequent lung infections. The purpose of this study is to explore an investigational medication that …
This study investigates the effects of an investigational medication on a specific medical condition. The purpose of this study is to understand how the investigational medication works in the body and its potential effects on the condition being studied.Participants in this study will undergo various procedures, which may include medical …
This study investigates the effects of vagal nerve stimulation during sinus surgery. The purpose is to see if this method can reduce bleeding and improve the view for surgeons. Functional endoscopic sinus surgery (FESS) is a procedure used to treat sinus issues. During this surgery, bleeding can make it hard …
This study investigates the safety and immune response of investigational vaccines for meningococcal disease, specifically targeting serogroup B, in healthy individuals across various age groups. The purpose is to compare these investigational vaccines with two licensed vaccines, focusing on their effects when given alone or with other routine vaccines. Meningococcal …
Who can participate: Adults aged 18-65 who have a history of migraines for at least one year and experience four or more migraine days per month are eligible to participate.Study details: Participants will receive either the investigational treatment or a placebo and will be monitored for changes in migraine frequency.
This study investigates an investigational medication combined with other agents to treat relapsed or refractory myeloma, a type of blood cancer. Myeloma affects plasma cells in the bone marrow and can cause bone pain, fatigue, and increased risk of infections. The study includes multiple substudies to explore different combinations and …
This study investigates the use of an investigational medication in people who have received or will receive a kidney transplant. Kidney transplantation is a procedure where a healthy kidney from a donor is placed into a person whose kidneys are not working properly. The study focuses on two groups, or …
This study investigates an investigational medication for adults with moderate to severe atopic dermatitis (AD). Atopic dermatitis is a condition that causes red, itchy skin. This study aims to understand the safety and effectiveness of the investigational medication in participants who have already been part of a previous trial involving …
