This study investigates the effects of using hemofilters and hemodialyzers on cytokine removal during cardiopulmonary bypass in children undergoing heart surgery. Cardiopulmonary bypass is a procedure that helps correct heart problems, but it can cause a reaction in the body called systemic inflammatory response syndrome (SIRS). This reaction involves various …
This study investigates the safety and effects of an investigational medication compared to a placebo in people with liver fibrosis and compensated cirrhosis. Liver fibrosis is a condition where scar tissue forms in the liver due to injury or long-term damage. Compensated cirrhosis means the liver is scarred but still …
This study investigates the effectiveness of two treatments for geographic atrophy, an eye condition that occurs in some older adults. Geographic atrophy is a form of age-related macular degeneration where parts of the retina deteriorate, leading to vision loss. The purpose of this study is to compare two treatments: an …
This study investigates the safety and effects of an investigational medication when given alone or combined with other treatments for cancer. The purpose is to find the best amount of the medication to use. The study focuses on people with solid tumors, which are abnormal cell lumps, that are advanced …
This study investigates the safety and effectiveness of an investigational medication compared to standard chemotherapy treatments. The focus is on patients with metastatic pancreatic ductal adenocarcinoma (PDAC), a type of cancer that has spread from the pancreas to other parts of the body. The study will compare two approaches: the …
This study investigates the safety, efficacy, and immune response of an investigational vaccine for acne. Acne vulgaris is a common skin condition that causes inflammation, particularly in teenagers and young adults. It affects millions of people worldwide and can significantly impact quality of life. The purpose of this study is …
This study investigates cold agglutinin disease (CAD) and cold agglutinin syndrome (CAS). These are conditions where the immune system mistakenly attacks red blood cells at low temperatures, causing them to clump together. The purpose of this study is to collect data on participants with these conditions to better understand their …
This study investigates the collection of data on cancer treatments and patient outcomes. The purpose is to understand the safety and effectiveness of anti-cancer therapies and the decisions made during treatment. This study involves a registry where information is gathered from cancer patients to analyze treatment decisions and their outcomes.Participants …
This study investigates pediatric patients with moderate to severe atopic dermatitis (AD). Atopic dermatitis is a chronic skin condition that causes itchy, inflamed skin. The purpose of this study is to describe the characteristics of these patients whose condition is not well controlled by topical treatments or when such treatments …
This study investigates the real-world use of an investigational medication in adults with prurigo nodularis (PN). Prurigo nodularis is a skin condition characterized by itchy, hard bumps on the skin. The purpose of this study is to observe how the investigational medication is used and how it works in everyday …
