This study investigates the safety and pharmacokinetics (how the body processes a drug) of an investigational medication in children with Chronic Spontaneous Urticaria (CSU). CSU is a condition characterized by recurrent itchy hives with or without swelling, lasting more than 6 weeks, despite treatment with H1-antihistamines. The study aims to …
This study investigates the effects of an investigational medication given after specific chemotherapy drugs, fludarabine and cytarabine, for treating adults with relapsed or refractory acute myeloid leukemia (AML). Acute myeloid leukemia is a type of cancer that affects the blood and bone marrow. The study aims to find the right …
This study investigates an investigational medication for patients with advanced cancer that cannot be removed by surgery or has spread to other parts of the body. These patients have not responded to or cannot receive standard approved treatments. The study consists of two parts: a dose escalation phase to find …
This study investigates the safety and effectiveness of an investigational medication in treating chronic graft-versus-host disease (cGVHD). cGVHD is a condition that can occur after a bone marrow or stem cell transplant, where the transplanted cells attack the recipient's body. This study focuses on Black or African American, American Indian …
This study investigates the safety and tolerability of an investigational medication for Fabry Disease (FD). Fabry Disease is a genetic disorder that affects the body's ability to break down a specific type of fat, leading to a buildup in the body's cells. The purpose of this study is to see …
This study investigates the use of a diagnostic screening tool to identify patients who may have Gaucher disease, a rare genetic disorder. The study involves three phases. In Phase I, a special algorithm will be used to analyze electronic health records (EHR) to find patients with a high likelihood of …
This study investigates the effects of an investigational medication on adults with eosinophilic esophagitis. Eosinophilic esophagitis is a condition where white blood cells called eosinophils build up in the esophagus, causing inflammation and swallowing difficulties. The purpose of this study is to evaluate how the investigational medication affects the function …
This study investigates whether using hydrogen peroxide before shoulder surgery can change the rates of P acnes bacteria found during surgery. P acnes is a type of bacteria that often causes infections after shoulder surgeries. Current methods to prevent these infections, like antibiotics and skin cleaning, are not very effective …
This study investigates the effectiveness of an investigational medication compared to a placebo in adults with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) who do not respond to standard treatments. CIDP is a condition where the body's immune system attacks the nerves, leading to weakness and numbness. The study aims to see …
This study investigates the effects of an investigational medication or vaccine on a specific condition. The purpose is to understand how the investigational treatment works and its potential effects on participants.Participants will undergo certain study procedures to monitor their health and any changes that occur during the study. These procedures …
