Inclusion Criteria:

• Participants must be ≥6 months to <18 years of age, at the time of signing the informed consent.
• A clinical diagnosis of prurigo nodularis (PN) at least 3 months prior to screening, an Investigator's global assessment for prurigo nodularis stage (IGA PN-S) score of ≥2 with presence of ≥6 pruriginous lesions at Baseline. The lesions should be present on ≥2 different body surface areas at Baseline.
• On the worst itch numerical rating scale (WI-NRS) (for participants aged ≥6 years to <18 years old at the screening visit) or worst-scratch/itch NRS (for participants aged ≥6 months to <6 years at the screening visit) ranging from 0 to 10, participants must have an average worst itch score of ≥7 in the 7 days prior to Day 1.

        NOTE: Baseline pruritus NRS average score for maximum itch intensity will be determined
        based on the average of daily NRS scores for maximum intensity (the daily score ranges from
        0 to 10) during the 7 days immediately preceding the Day 1/Baseline visit. A minimum of 4
        daily scores out of the 7 days is required to calculate the baseline average score.
          -  Participants/Caregivers must be willing and able to complete a daily symptom e-Diary
             for the duration of the study.
          -  Contraceptive use by male and female participants should be consistent with local
             regulations regarding the methods of contraception for those participating in clinical
             studies.
        Exclusion Criteria:
        Participants are excluded from the study if any of the following criteria apply:
          -  Presence of active moderate to severe lesions of atopic dermatitis (AD), and/or other
             skin conditions that may interfere with the PN diagnosis including but not limited to
             the following: scabies, psoriasis, lymphomatoid papulosis, habitual picking,
             dermatitis herpetiformis, sporotrichosis, and bullous disease.
          -  Active chronic or acute infection requiring treatment with systemic antibiotics,
             antivirals, or antifungals within 2 weeks before the screening visit or during the
             screening period.
        NOTE: Participants may be rescreened after infection resolves.
          -  Known or suspected immunodeficiency, including history of invasive opportunistic
             infections (eg, histoplasmosis, listeriosis, coccidioidomycosis, pneumocystosis, and
             aspergillosis) despite infection resolution, or otherwise recurrent infections of
             abnormal frequency or prolonged duration suggesting an immune compromised status, as
             judged by the Investigator.
          -  Severe concomitant illness(es) that, in the Investigator's judgment, would adversely
             affect the participant's participation in the study.
          -  Planned or anticipated major surgical procedure during the participant's participation
             in this clinical trial.
          -  Participants who has taken biologic therapy/systemic immunosuppressant/
             immunomodulator within 4 weeks before the screening visit or 5 half-lives, whichever
             is longer.
          -  Current participation to any clinical trial of an investigational drug or device or
             participation within 3 months before the screening visit or 5 half-lives of the
             investigational compound, whichever is longer.
          -  Participation in prior dupilumab clinical study or have been treated with commercially
             available dupilumab.